This post is following on from my last post “Could CBD help treat Perthes Disease?”
Over the past couple of weeks I’ve learned a lot more about how the body reacts to different compounds and molecules, how they have effects on different cells in the body and that normal cell function is very important to maintain an ideal balance within the body which in turn prevents illness and disease.
By the time I had done my research, had taken in all of the information available and put it all together I came to my own conclusion that Cannabidiol (CBD) would be able to help assist with the pain and inflammation symptoms that arise from the very onset of Perthes Disease. Studies showed that CBD along with THC also produced signs of helping with bone regeneration which would be a perfect supplement to take to help in the fragmentation and re-ossification stages of the disease, which can last several years. The disease starts off with the hip area/s becoming intensely inflamed, causing blood obstruction to the femoral head which leads to the bone cells dying, pain and inflammation in the affected area/s.
Pain is caused due to microglia activation in the brain and spinal cord which then triggers the release of the pro-inflammatory cytokines involved in the initiation of neuropathic pain.
Cytokines are small proteins that are important in cell signalling and their release has an effect on the behaviour of cells around them.
CBD has been shown to inhibit cell signalling through the GPR55 and TRP receptors which then reduces the cytokine release. This would help with the hip, knee and other pain associated with Perthes Disease.
Inflammation is caused by a response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants and is a protective response involving immune cells, blood vessels, and molecular mediators.
The function of inflammation is to eliminate the initial cause of cell injury, to clear out necrotic cells and tissues damaged from the original insult and to initiate tissue repair.
CBD has been shown to reduce inflammation and neuropathic pain by targeting the a3 glycine receptors, which are neurotransmitters and are the most abundant receptors in the central nervous system. Glycine receptors mediate neurotransmission in the spinal cord and brain-stem.
Because not a lot is known about Perthes Disease I couldn’t find any information relating specifically to the disease itself and CBD and/or THC use but I did find information relating to bones and fractures and how bones naturally heal.
Bone fractures and injuries heal through callus formation, creating cross-bridges from osteoblast cell proliferation. Usually in the case of broken or damaged bones, 2-6 weeks after the trauma, a process occurs whereby the fragile cartilage material of the soft callus is transformed and completely woven into new bone. When a healthy bone is damaged the woven bone is usually repaired over a few weeks and heals up quite fast but in Perthes Disease the woven bone is constantly being replaced over a number of years until the disease has taken it’s course, the reasons behind this are unknown due to the disease being rare.
Studies have suggested that CBD and THC stimulates the receptors on bone cells that have cannabinoid ligands and vastly improves the rate of bone healing. Hard callus formation is a complex process that is guided by the release of mineral compounds such as calcium and phosphate into the cartilage tissue, which subsequently transforms into hard callus over the injury site. When CBD or THC was used callus size was increased and at faster speeds.
CBD enhanced and significantly strengthened the bones and mechanical properties while THC increased the maximal force and stiffness of the bones.
The whole length and process of the disease is unknown because each child is different and Perthes Disease affects boys and girls differently.
BOSS Study Trials are currently underway at The University of Liverpool in a nationwide UK study of surgery for Slipped Capital Femoral Epiphysis and Perthes’ Disease of which my Son is a candidate in the trials. The university collect routine information about Cole’s diagnosis, x-ray findings and the treatments undertaken. Cole’s next appointment at the Ortho Clinic is in a couple of weeks and I will be speaking to his consultant and asking his opinions on the possibilities of CBD helping in the treatment of this disease and I will update my blog with his response.
Before I finish I must say I’m not a medical expert and all the information I have gathered has come from my own research. Because CBD is not classed as a medicine the relevant medical studies for this particular disease have not yet been carried out.